从1994年 FGFR3靶点被证实与ACH相关，到2021年Vosoritide获批上市，ACH患者等待了近30年，才迎来首款针对性治疗药物。而随着Infigratinib叩响上市的大门，以及身后一众迭代疗法的逼近，ACH精准治疗的新大门正加速开启。这也是罕见病从被行业忽略到逐渐被重视的真实缩影。
What do we know about the two bids?
Existing Measures Are Sufficient，这一点在同城约会中也有详细论述
It’s Not AI Psychosis If It Works#Before I wrote my blog post about how I use LLMs, I wrote a tongue-in-cheek blog post titled Can LLMs write better code if you keep asking them to “write better code”? which is exactly as the name suggests. It was an experiment to determine how LLMs interpret the ambiguous command “write better code”: in this case, it was to prioritize making the code more convoluted with more helpful features, but if instead given commands to optimize the code, it did make the code faster successfully albeit at the cost of significant readability. In software engineering, one of the greatest sins is premature optimization, where you sacrifice code readability and thus maintainability to chase performance gains that slow down development time and may not be worth it. Buuuuuuut with agentic coding, we implicitly accept that our interpretation of the code is fuzzy: could agents iteratively applying optimizations for the sole purpose of minimizing benchmark runtime — and therefore faster code in typical use cases if said benchmarks are representative — now actually be a good idea? People complain about how AI-generated code is slow, but if AI can now reliably generate fast code, that changes the debate.
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